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effect of ambient temperature on serotonin syndrome

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Date Issued:
2008
Summary:
Serotonin syndrome (SS) is a drug-induced toxicity caused by an excess of serotonin (5-HT) in the central nervous system (CNS). The symptoms of the disorder range from mild to severe, with the severe state evoking life-threatening hyperthermia. Autonomic dysfunction is controlled in part by serotonin receptors, with the 5-HT2A receptor responsible for increasing core body temperature (Tcor). Our results show that the 5-HT2A receptors on the preoptic/anterior hypothalamus (PO/AH) and prefrontal cortex (PFC), in particular, are sensitive to changes in ambient temperature (Tamb). The toxic increase of 5-HT is postulated to occur due to the temperature-dependent activation of these receptors that promotes a positive feedback mechanism. Our results suggest that changes in Tamb can either exacerbate or alleviate the symptom and that this is mediated by the 5-HT2A receptors. Understanding the mechanism involved in elevating Tcor is imperative in treating and preventing the disorder.
Title: The effect of ambient temperature on serotonin syndrome.
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Name(s): Krishnamoorthy, Swapna.
Charles E. Schmidt College of Medicine
Type of Resource: text
Genre: Electronic Thesis Or Dissertation
Issuance: monographic
Date Issued: 2008
Publisher: Florida Atlantic University
Physical Form: electronic
Extent: xiv, 168 p. : ill. (some col.).
Language(s): English
Summary: Serotonin syndrome (SS) is a drug-induced toxicity caused by an excess of serotonin (5-HT) in the central nervous system (CNS). The symptoms of the disorder range from mild to severe, with the severe state evoking life-threatening hyperthermia. Autonomic dysfunction is controlled in part by serotonin receptors, with the 5-HT2A receptor responsible for increasing core body temperature (Tcor). Our results show that the 5-HT2A receptors on the preoptic/anterior hypothalamus (PO/AH) and prefrontal cortex (PFC), in particular, are sensitive to changes in ambient temperature (Tamb). The toxic increase of 5-HT is postulated to occur due to the temperature-dependent activation of these receptors that promotes a positive feedback mechanism. Our results suggest that changes in Tamb can either exacerbate or alleviate the symptom and that this is mediated by the 5-HT2A receptors. Understanding the mechanism involved in elevating Tcor is imperative in treating and preventing the disorder.
Identifier: 317858074 (oclc), 186297 (digitool), FADT186297 (IID), fau:2864 (fedora)
Note(s): by Swapna Krishnamoorthy.
Vita.
Thesis (M.S.)--Florida Atlantic University, 2008.
Includes bibliography.
Electronic reproduction. Boca Raton, Fla., 2008. Mode of access: World Wide Web.
Subject(s): Serotoninergic mechanisms
Central nervous system -- Physiology
Body temperature -- Regulation
Neurotransmitter receptors
Serotonin -- Physiological effect
Held by: FBoU FAUER
Persistent Link to This Record: http://purl.flvc.org/FAU/186297
Use and Reproduction: http://rightsstatements.org/vocab/InC/1.0/
Host Institution: FAU