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RNA oxidative damage and ribosomal RNA surveillance under oxidative stress
| Title: | RNA oxidative damage and ribosomal RNA surveillance under oxidative stress. |
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| Name(s): |
Liu, Min Charles E. Schmidt College of Science Department of Biological Sciences |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Issued: | 2012 | |
| Publisher: | Florida Atlantic University | |
| Physical Form: | electronic | |
| Extent: | xii, 148 p. : ill. (some col.) | |
| Language(s): | English | |
| Summary: | We have studies oxidative damage of RNA, a major type of cellular macromolecules. RNA is a primary target of reactive oxygen species (ROS). Under oxidative stress, most nucleic acid damages in Escherichia coli (E.coli) are present in RNA as shown by high levels of 8-oxo-G, an oxidized form of guanine. Increased RNA oxidation is closely correlated to cell death under oxidative stress. Surprisingly, neither RNA structure nor association with proteins protects RNA from oxidation... Our results demonstrate a major role for RNA degradation in controlling oxidized RNA. We have identified activities that may work in specific pathways for selectively degrading damaged RNA. These activities may play pivotal rold in controlling oxidized RNA and protecting cells under oxidative stress. | |
| Identifier: | 820360151 (oclc), 3355620 (digitool), FADT3355620 (IID), fau:3946 (fedora) | |
| Note(s): |
by Min Liu. Thesis (Ph.D.)--Florida Atlantic University, 2012. Includes bibliography. Mode of access: World Wide Web. System requirements: Adobe Reader. |
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| Subject(s): |
RNA -- Metabolism Cellular signal transduction Genetic translation Molecular biology |
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| Persistent Link to This Record: | http://purl.flvc.org/FAU/3355620 | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU |
