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A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli
| Title: | A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli. |
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| Name(s): |
Coval, S. J., creator Patton, R. W., creator Petrin, J. M., creator James, L., creator Rothofsky, M. L., creator Lin, S. L., creator Patel, Mahesh, creator Reed, John K., creator McPhail, A. T., creator Bishop, W. R., creator |
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| Type of Resource: | text | |
| Genre: | Article | |
| Issuance: | single unit | |
| Date Issued: | 1996 | |
| Publisher: | Elsevier B.V. | |
| Extent: | 5 p. | |
| Physical Description: | ||
| Language(s): | English | |
| Identifier: | 3331913 (digitool), FADT3331913 (IID), fau:6151 (fedora), 10.1016/0960-894X(96)00142-4 (doi) | |
| Note(s): |
A previously described cembranolide diterpene from Lobophytum cristagalli was identified as a potent (IC50 0.15 μM) inhibitor of farnesyl protein transferase (FPT). The compound showed selectivity for FPT as compared to the closely related enzyme geranylgeranyl protein transferase-1 (IC50 5.3 μM). Kinetic evaluation suggests that this compound competes with the protein/peptide farnesyl acceptor substrate, and not with farnesyl pyrophosphate for inhibition of FPT. This manuscript is an author version with the final publication available at http://www.sciencedirect.com/science/journal/0960894X and may be cited as: Coval, S. J., Patton, R. W., Petrin, J. M., James, L., Rothofsky, M. L., Lin, S. L., Patel, M., Reed, J. K., McPhail, A. T., & Bishop, W. R. (1996). A cembranolide diterpene farnesyl protein transferase inhibitor from the marine soft coral Lobophytum cristagalli. Bioorganic & Medicinal Chemistry Letters, 6(7), 909-912. doi:10.1016/0960-894X(96)00142-4 Florida Atlantic University. Harbor Branch Oceanographic Institute contribution #1131. |
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| Subject(s): |
Corals Alcyoniidae Ras proteins Diterpenes Antineoplastic agents |
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| Persistent Link to This Record: | http://purl.flvc.org/FCLA/DT/3331913 | |
| Links: | http://dx.doi.org/10.1016/0960-894X(96)00142-4 | |
| Restrictions on Access: | ©1996 Elsevier B.V. | |
| Host Institution: | FAU |
