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Impact of Vitamin C on Genistein-Induced Apoptosis in Prostate Cancer
| Title: | Impact of Vitamin C on Genistein-Induced Apoptosis in Prostate Cancer. |
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| Name(s): |
Famuyiwa, Toluleke, author Kumi-Diaka, James, Thesis advisor Florida Atlantic University, Degree grantor Charles E. Schmidt College of Science Department of Biological Sciences |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Created: | 2015 | |
| Date Issued: | 2015 | |
| Publisher: | Florida Atlantic University | |
| Place of Publication: | Boca Raton, Fla. | |
| Physical Form: | application/pdf | |
| Extent: | 118 p. | |
| Language(s): | English | |
| Summary: | This study determined the impact of vitamin C dose on genistein-induced apoptosis in LNCaP cancer cells at various treatment regimens in vitro. Although the linear regression of viability assay (MTT) indicated a p-value = 0.11; NBT assay reveal a declining SOD activity during cell death. Apoptosis induction was the main mode of treatment induced cell death. The overall data showed the trend of treatment efficacy as;(Gen 10uM + Vit C 40uM) > (Gen 30uM + Vit C 40uM) > (Gen 70uM + Vit C 40uM) > 10uM genistein > 70uM genistein. The chi-square test for comparing necrosis, apoptosis and life cells showed that Vitamin C could impact genistein-induced apoptosis in LNCaP cells (p = 0.0003). This study forms the basis for in vivo studies of the impact of vitamin C on genistein-induced apoptosis in LNCaP prostate cancer cells. | |
| Identifier: | FA00004497 (IID) | |
| Degree granted: | Thesis (M.S.)--Florida Atlantic University, 2015. | |
| Collection: | FAU Electronic Theses and Dissertations Collection | |
| Note(s): | Includes bibliography. | |
| Subject(s): |
Apoptosis -- Molecular aspects Cellular signal transduction Genistein -- Therapeutic use Phytochemicals -- Physiological effect Phytochemicals -- Therapeutic use Prostate -- Cancer -- Adjuvant treatment Prostate -- Cancer -- Molecular aspects Vitamin C -- Therapeutic use |
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| Held by: | Florida Atlantic University Libraries | |
| Sublocation: | Digital Library | |
| Links: | http://purl.flvc.org/fau/fd/FA00004497 | |
| Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00004497 | |
| Use and Reproduction: | Copyright © is held by the author, with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU | |
| Is Part of Series: | Florida Atlantic University Digital Library Collections. |
