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Diversity and selection in the major histocompatibility complex
| Title: | Diversity and selection in the major histocompatibility complex: DQA and immune function in IRL and Atlantic bottlenose dolphins (Tursiops truncatus). |
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| Name(s): |
Ferrer, Tatiana. Charles E. Schmidt College of Science Department of Biological Sciences |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Issued: | 2013 | |
| Publisher: | Florida Atlantic University | |
| Physical Form: | electronic | |
| Extent: | x, 75 p. : ill. (some col.) | |
| Language(s): | English | |
| Summary: | The Major Histocompatibility Complex (MHC) encodes proteins critical to the vertebrate immune response; therefore MHC diversity is an indicator of population health. I have (1) Isolated exon 2 of the class II gene DQA in Tursiops truncatus in the North Indian River Lagoon (IRL) (n=17), South IRL (n=29) and adjacent Atlantic waters (n=20), (2) assessed genetic variability between groups, (3) developed a method to genotype individuals, (4) typed 11 unique alleles in 66 individuals, (5) detected geographic patterns of diversity between estuarine and coastal individuals (FST=0.1255, p<0.05), (6) found evidence of positive selection centered in the binding pockets P1, P6 and P9 of the peptide binding region (w=2.08), (7) found that patterns of polymorphism did not closely match patterns of diversity in neutral markers, (8) performed a pilot study with Orcinus orca. The initial findings highlight the need for further comparative work and suggest that silent mutations are not neutral. | |
| Identifier: | 858866559 (oclc), 3362335 (digitool), FADT3362335 (IID), fau:4173 (fedora) | |
| Note(s): |
by Tatiana Ferrer. Thesis (M.S.)--Florida Atlantic University, 2013. Includes bibliography. Mode of access: World Wide Web. System requirements: Adobe Reader. |
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| Subject(s): |
Major histocompatibility complex Immunogenetics Molecular genetics Endocrine disrupting chemicals Dolphins -- Atlantic Ocean -- Geographical distribution Population genetics Social behavior in animals |
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| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/3362335 | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU |
