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Development of a novel assay for in vivo screening of neuromodulatory drugs and targeted disruption of cholinergic synaptic transmission in Drosophila melanogaster
| Title: | Development of a novel assay for in vivo screening of neuromodulatory drugs and targeted disruption of cholinergic synaptic transmission in Drosophila melanogaster. |
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| Name(s): |
Mejia, Monica Charles E. Schmidt College of Science Department of Biological Sciences |
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| Type of Resource: | text | |
| Genre: | Electronic Thesis Or Dissertation | |
| Date Issued: | 2013 | |
| Publisher: | Florida Atlantic University | |
| Physical Form: | electronic | |
| Extent: | xv,148 p. : ill. (some col.) | |
| Language(s): | English | |
| Summary: | Finding novel compounds that affect neuronal or muscular function is of great interest, as they can serve as potential pharmacological agents for a variety of neurological disorders. For instance, conopeptides have been developed into powerful drugs like the painkiller PrialtTM. Most conopeptides, however, have yet to be characterized, revealing the need for a rapid and straightforward screening method. We have designed a novel bioassay, which allows for unbiased screening of biological activity of compounds in vivo against numerous molecular targets on a wide variety of neurons and muscles in a rapid and straightforward manner. For this, we paired nanoinjection of compounds with electrophysiological recordings from the Giant Fiber System of Drosophila melanogaster, which mediates the escape response of the fly. | |
| Identifier: | 862395506 (oclc), 3362560 (digitool), FADT3362560 (IID), fau:4208 (fedora) | |
| Note(s): |
by Monica Mejia. Thesis (Ph.D.)--Florida Atlantic University, 2013. Includes bibliography. Mode of access: World Wide Web. System requirements: Adobe Reader. |
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| Subject(s): |
Drosophila melanogaster -- Genetics Drosophila melanogaster -- Life cycles Insects -- Physiology Developmental neurobiology Neural transmission Cholinergic mechanisms |
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| Persistent Link to This Record: | http://purl.flvc.org/fcla/dt/3362560 | |
| Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
| Host Institution: | FAU |
