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Combination of Sulindac and Metformin as a Therapeutic Target in Lung Cancer
- Date Issued:
- 2020
- Abstract/Description:
- Sulindac is an FDA approved, non-steroidal anti-inflammatory drug that exhibits anti-cancer properties. Metformin is and FDA approved, anti-diabetic drug that also has documented anti-cancer properties. The goal of this project was to explore if a dual-combination of sulindac and metformin in the presence of a chemical oxidizing agent is more effective in killing lung cancer cells while not inducing cell death in normal lung cells. Our data shows that a triple-drug combination of sulindac, metformin, and tert-butyl hydroperoxide induce significant cell death in lung cancer cells but did not induce significant cell death in normal lung cells.
Title: | Combination of Sulindac and Metformin as a Therapeutic Target in Lung Cancer. |
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Name(s): |
Butler, Heather , author Trivigno, Catherine, Thesis advisor Florida Atlantic University Harriet L. Wilkes Honors College |
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Type of Resource: | text | |
Genre: | Thesis | |
Date Created: | 2020 | |
Date Issued: | 2020 | |
Publisher: | Florida Atlantic University Digital Library | |
Place of Publication: | Boca Raton, Fla. | |
Physical Form: | online resource | |
Extent: | 32 p. | |
Language(s): | English | |
Abstract/Description: | Sulindac is an FDA approved, non-steroidal anti-inflammatory drug that exhibits anti-cancer properties. Metformin is and FDA approved, anti-diabetic drug that also has documented anti-cancer properties. The goal of this project was to explore if a dual-combination of sulindac and metformin in the presence of a chemical oxidizing agent is more effective in killing lung cancer cells while not inducing cell death in normal lung cells. Our data shows that a triple-drug combination of sulindac, metformin, and tert-butyl hydroperoxide induce significant cell death in lung cancer cells but did not induce significant cell death in normal lung cells. | |
Identifier: | FA00003700 (IID) | |
Degree granted: | Thesis (B.A.)--Florida Atlantic University, Harriet L. Wilkes Honors College, 2020. | |
Collection: | Florida Atlantic University Digital Library Collections | |
Note(s): | Includes bibliography. | |
Persistent Link to This Record: | http://purl.flvc.org/fau/fd/FA00003700 | |
Use and Reproduction: | Copyright © is held by the author with permission granted to Florida Atlantic University to digitize, archive and distribute this item for non-profit research and educational purposes. Any reuse of this item in excess of fair use or other copyright exemptions requires permission of the copyright holder. | |
Use and Reproduction: | http://rightsstatements.org/vocab/InC/1.0/ | |
Host Institution: | FAU |